PHARMACEUTICAL COMBINATION PREPARATION CONTAINING THE INHIBITOR OF HMG-CoA REDUCTASE AND INHIBITOR OF CHOLESTEROL ABSORPTION

摘要

FIELD: chemical-pharmaceutical industry.;SUBSTANCE: invention relates to the chemical and pharmaceutical industry and is a pharmaceutical combination preparation for the treatment of disorders, arising from increased cholesterol, containing from 5 to 15 parts by weight of rosuvastatin or its pharmaceutically acceptable salts; from 5 to 15 parts by weight of ezetimibe or its pharmaceutically acceptable sa from 4.5 to 12 parts by weight of sodium starch glycolate; and from 20 to 35 parts by weight of hydroxypropylcellulose with a low degree of substitution with respect to 100 parts by weight of the total weight of the pharmaceutical combination preparation.;EFFECT: invention makes it possible to significantly improve the convenience of administering a medicament to a patient, since two types of drugs are contained in one preparation and the pattern of dissolution of these two types of drugs when dissolving the combined preparation is the same as the dissolution pattern of each drug in a single ingredient formulation.;10 cl, 3 dwg, 2 ex, 7 tbl