INHIBITORS OF 17ß-HSD1, 17ß-HSD3 AND 17ß-HSD10

摘要

The present application discloses 17 hydroxy steroid dehydrogenase (17 HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17 HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17 HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17 HSD1 and 17 HSD3 that have a spiro-morpholine substituent at C20.