3,4-BROMO OR -SULFONATE SUBSTITUTED 1H-PYRROLE-2,5-DIONE DERIVATIVES AS TYPE III DEIODINASE (DIO3) INHIBITORS FOR TREATING DEPRESSIONS AND CANCER

摘要

The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.