3,4-BIS-(3,3'-INDOLYL)-1H-PYRROLE-2,5-DIONE DERIVATIVES WHICH ARE CYCLISED THROUGH THE 1,1'-POSITIONS OF THE INDOLE RINGS; PHARMACEUTICAL COMPOSITIONS

摘要

This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: CHEM The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.