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HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
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机译:人PD-1基因敲低SIRNA,重组表达CAR-T向量,其制备方法及应用
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摘要
Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.
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