CRYSTALLINE FORMS OF MESYLATE SALT OF PYRIDINYL AMINO PYRIMIDINE DERIVATIVE, PREPARATION METHODS THEREFOR, AND APPLICATIONS THEREOF

摘要

The present invention provides crystalline form I and crystalline form II of a mesylate salt of a pyridinyl amino pyrimidine derivative and preparation methods therefor, a pharmaceutical composition containing the crystalline forms, and applications of the crystalline forms in the treatment of activated EGFR mutant- or drug-resistant mutant-mediated diseases, especially cancer, in mammals, particularly humans. The crystalline forms of the mesylate salt of the compound represented by formula (I) have good solubility and high bioavailability in animals