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ODORANT RECEPTOR CO-RECEPTOR

机译:气味接受者共同接受者

摘要

Provided is an insect odorant receptor co-receptor that exhibits excellent detection sensitivity to an odorous substance when bound to an odorant receptor to form an odorant receptor complex. The odorant receptor co-receptor of the invention includes the following first amino acid sequence and the following second amino acid sequence subsequently to the farthest carboxyl-terminal amino acid residue of the first amino acid sequence: (1) a first amino acid sequence, which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the co-receptor, the partial amino acid sequence being an amino acid sequence that is contiguous from the amino-terminus of the odorant receptor co-receptor of the first insect or a variant of the co-receptor to any one amino acid residue positioned in the range of twenty amino acid residues before and after the farthest carboxyl -terminal amino acid residue of the fourth transmembrane domain; and (2) a second amino acid sequence, which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a variety different from the first insect or a variant of the co-receptor, the partial amino acid sequence being an amino acid sequence that is contiguous from an amino acid residue at a position that is on position one carboxyl-terminal to a position corresponding, in an alignment analysis of the amino acid sequence of the first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, to the farthest carboxyl-terminal amino acid residue of the first amino acid sequence in the odorant receptor co-receptor of the second insect or a variant of the co-receptor, to the carboxyl-terminus of the odorant receptor co-receptor of the second insect or a variant of the co-receptor.
机译:提供了一种昆虫气味受体共受体,当与气味受体结合形成气味受体复合物时,其对气味物质表现出优异的检测灵敏度。本发明的加味剂受体共受体在第一氨基酸序列的最远羧基末端氨基酸残基之后包括以下第一氨基酸序列和以下第二氨基酸序列:(1)第一氨基酸序列,其中是第一昆虫或该共受体变体的气味受体共受体的部分氨基酸序列,该部分氨基酸序列是与该气味受体共受体的氨基末端连续的氨基酸序列。第一昆虫的受体或该共受体的变体对位于第四跨膜结构域的最远羧基末端氨基酸残基之前和之后的二十个氨基酸残基范围内的任何一个氨基酸残基的受体; (2)第二氨基酸序列,其是不同于第一昆虫或该共受体变体的第二昆虫的气味受体共受体的部分氨基酸序列,该部分氨基酸序列在第一种昆虫气味受体共受体或变体的氨基酸序列的比对分析中,是在一个羧基末端的一个氨基酸末端与一个对应的位置的氨基酸残基连续的氨基酸序列在第二昆虫的气味受体共受体或其变体中,其与第二昆虫气味受体共受体或其变体的氨基酸序列至第一氨基酸序列中最远的羧基末端氨基酸残基。第二昆虫的气味受体共同受体的羧基末端的共同受体或共同受体的变体。

著录项

  • 公开/公告号EP3521427A1

    专利类型

  • 公开/公告日2019-08-07

    原文格式PDF

  • 申请/专利权人 SUMITOMO CHEMICAL COMPANY LIMITED;

    申请/专利号EP20170856153

  • 发明设计人 TAKAHASHI YASUHIKO;TAKAKU TOMOYUKI;

    申请日2017-09-26

  • 分类号C12N15/09;C07K14/705;C07K19;C12N1/15;C12N1/19;C12N1/21;C12N5/10;

  • 国家 EP

  • 入库时间 2022-08-21 12:26:44

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