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METHOD FOR HIGHLY SENSITIVE BIOMARKER QUANTIFICATION USING PHOTO-OXIDATION AMPLIFICATION
METHOD FOR HIGHLY SENSITIVE BIOMARKER QUANTIFICATION USING PHOTO-OXIDATION AMPLIFICATION
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机译:光氧化放大高灵敏度生物标记定量的方法
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摘要
Disclosed is a method of quantifying a biomarker with high sensitivity using photo-oxidation induced amplification. The method includes performing an enzyme-substrate reaction of a measurement sample including an enzyme labeled on any one selected from among an antibody, an aptamer, and a nucleic acid specifically bound to the biomarker, optically measuring one or more optical properties selected from among amounts of color formation, light emission, and fluorescence of a product during a photo-oxidation induced amplification process while the product resulting from the enzyme-substrate reaction is continuously exposed to light to thus perform the photo-oxidation induced amplification process, indexing a time-varying pattern of the measured optical properties, and quantifying a concentration of the biomarker included in the measurement sample by comparing an index extracted during the indexing with an index of a reference sample.
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