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METHOD FOR CONTROLLING AFFINITY OF ANTIBODY FOR ANTIGEN, ANTIBODY WHOSE AFFINITY FOR ANTIGEN HAS BEEN ALTERED, AND ITS PRODUCTION METHOD
METHOD FOR CONTROLLING AFFINITY OF ANTIBODY FOR ANTIGEN, ANTIBODY WHOSE AFFINITY FOR ANTIGEN HAS BEEN ALTERED, AND ITS PRODUCTION METHOD
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机译:控制抗原亲和力的方法,已改变抗原亲和力的抗体及其生产方法
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摘要
PROBLEM TO BE SOLVED: To provide techniques for controlling affinity of an antibody for an antigen, and an antibody whose affinity for an antigen has been altered.;SOLUTION: The problem is solved by substituting charged amino acid residues for at least 3 amino acid residues of a specific framework region defined by the Chothia method in an antibody in accordance with electrical characteristics of a complementarity determining region (CDR) based on the amino acid sequence of the CDR.;SELECTED DRAWING: None;COPYRIGHT: (C)2019,JPO&INPIT
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