METHOD FOR CONTROLLING AFFINITY OF ANTIBODY FOR ANTIGEN, ANTIBODY WHOSE AFFINITY FOR ANTIGEN HAS BEEN ALTERED, AND ITS PRODUCTION METHOD

摘要

PROBLEM TO BE SOLVED: To provide techniques for controlling affinity of an antibody for an antigen, and an antibody whose affinity for an antigen has been altered.;SOLUTION: The problem is solved by substituting charged amino acid residues for at least 3 amino acid residues of a specific framework region defined by the Chothia method in an antibody in accordance with electrical characteristics of a complementarity determining region (CDR) based on the amino acid sequence of the CDR.;SELECTED DRAWING: None;COPYRIGHT: (C)2019,JPO&INPIT