SYSTEMIC DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR CARDIOVASCULAR DISEASES AND OTHER CONDITIONS

摘要

To provide a method for treating, ameliorating or protecting (preventing) an individual or patient against a disease, infection or condition responsive to an increased or sustained paracrine polypeptide level in vivo.SOLUTION: The method comprises, e.g., providing either: a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, vector, recombinant virus or equivalent, having contained therein a paracrine-encoding nucleic acid, gene, transcript or message, where the expression vehicle, vector, recombinant virus or equivalent can express the paracrine-encoding nucleic acid, gene, transcript or message in a cell or in vivo.SELECTED DRAWING: None