SYSTEMIC DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR CARDIOVASCULAR DISEASES AND OTHER CONDITIONS

摘要

In an alternative embodiment, the invention provides a paracrine polypeptide-encoding nucleic acid or gene operably linked to a transcriptional regulatory sequence; Or an expression vehicle, vector, recombination containing a paracrine-encoding nucleic acid, gene, transcript or message therein that can express a paracrine-encoding nucleic acid, gene, transcript or message in cells or in vivo Providing a virus or equivalent; Increased paracrine by administering or delivering to a subject or patient in need thereof a paracrine polypeptide-encoding nucleic acid, gene, transcript or message, or expression vehicle, vector, recombinant virus or equivalent operably linked to a transcriptional regulatory sequence. Treating, ameliorating or protecting (preventing) the individual or patient of the disease, infection or symptom responsive to the polypeptide level, the individual of the disease, infection or symptom responsive to increased or persistent paracrine polypeptide levels in vivo. Or provide a method of treating, improving or protecting (preventing) a patient.