HUMAN MONOCLONAL ANTIBODY AGAINST PROGRAMMED DEATH 1 (PD-1) AND METHOD FOR TREATING CANCER USING ANTI-PD-1 ANTIBODY ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPY

摘要

To provide an isolated monoclonal antibody specifically binding to Programmed Death 1 (PD-1) with high affinity, particularly a human monoclonal antibody.SOLUTION: The present invention provides an isolated monoclonal antibody or a binding portion thereof, which performs a cross-competition for binding to a reference antibody comprising a human heavy chain and light chain variable regions consisting of specific amino acid sequences and PD-1. According to the present invention, by preparing an immunocomplex, a bispecific molecule, and a pharmaceutical composition, which are comprising the antibody, it is possible to provide a PD-1 detection method and treat various disorders including cancer and infectious diseases. According to the present invention, it is also possible to treat hyperproliferative disorders, such as cancer, using a combination immunotherapy, such as a combination of anti-CTLA-4 and anti-PD-1 antibodies. Adverse treatment-related adverse events by each of such antibodies are altered.SELECTED DRAWING: None