CONJUGATES COMPRISING CELL-BINDING AGENTS AND MAYTANSINOIDS AS CYTOTOXIC AGENTS

摘要

To provide linker compounds and cytotoxic compounds that are useful for forming a CBA (cell-binding agent)-drug conjugate.SOLUTION: The present invention provides a conjugate represented by the following formula, or a pharmaceutically acceptable salt thereof [CBA is a cell binding agent; DM is a drug moiety represented by a specific chemical formula], provided that the CBA does not comprise a modified lysine residue carrying a free thiol (-SH) group.SELECTED DRAWING: None