Tissue regeneration using somatic cell nuclear transfer (SCNT) cells and blastocyst complementation

摘要

The present inventors have developed the injection of somatic cell nuclear transfer cells (SCNT cells) into blastocysts developed in the first non-human mammal leading to a lack of development of the target organ in the first non-human mammal. It is disclosed that the target organ such as the kidney can be regenerated by complementing the deficiency of. In addition, the present inventors are a method of producing a target organ in vivo in a first non-human mammal having an abnormality associated with lack of development of the target organ at the developmental stage using SCNT cells, which is a target Disclosed are methods wherein the organ is produced from a second mammal, which is an individual different from the first non-human mammal.