COPY NUMBER MEASUREMENT DEVICE, COPY NUMBER MEASUREMENT PROGRAM, COPY NUMBER MEASUREMENT METHOD AND GENE PANEL

摘要

To enable the correct copy number to be obtained in the target sequence.SOLUTION: A position identification unit 110 identifies the target position being the genome position of the base changing with respect to the human genomic sequence for each target gene by mapping a plurality of tumor sample reeds in the human genomic sequence. A frequency calculation unit 120 calculates a variant allele frequency for each target position of each target gene. A distance calculation unit 130 calculates a feature distance equivalent to the difference between the variant allele frequency corresponding to the peak density in the density distribution indicating the density with respect to the variant allele frequency of the mapping reed number and the reference variant allele frequency for each target gene. A coefficient calculation unit 140 calculates a correction coefficient using the feature distance for each target gene. A copy number calculation unit 150 calculates the copy number for each target gene in the cancer cell using the copy number and correction coefficient for each target gene in the tumor sample.SELECTED DRAWING: Figure 1