ENHANCERS FOR ANTI-TUMOR EFFECT OF ONCOLYTIC VIRUS

摘要

To provide agents to enhance antitumor effect in oncolytic viral therapies.SOLUTION: An agent comprising an ATM kinase inhibitor as the effective ingredient is used to enhance the antitumor effect of an oncolytic virus when concomitantly administered with the oncolytic virus. Preferably, the ATM kinase inhibitor is (2R,6S-rel)-2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetoamide or 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None