PROBLEM TO BE SOLVED: To provide an isolated H3 type equine influenza virus type A, to provide a method for preparing the virus, a gene or protein thereof, and to provide a method for use thereof.SOLUTION: The invention relates to an isolated H3 type equine influenza virus type A having a characteristic substitution in residues 78 and 159 of a hemagglutinin (HA) (numbering of positions is performed in a mature protein which lacks 15 amino acid signal peptide), i.e. having an amino acid in which the HA residue 78 is not valine, the HA residue 159 is not asparagine, the virus having a residue other than methionine at position 29, e.g., a non-conservative substitution, a residue other than lysine at position 54, e.g., a non-conservative substitution, a residue other than serine at position 83, e.g., a non-conservative substitution, a residue other than asparagine at position 92, e.g., a non-conservative substitution, a residue other than leucine at position 222, e.g., a non-conservative substitution, a residue other than alanine at position 272, e.g., a conservative substitution, and/or a residue other than threonine at position 328, e.g., a conservative substitution. The invention also relates to a vaccine containing the same.SELECTED DRAWING: None
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