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Method for producing scaffold for cell proliferation having structure memory characteristics

机译:具有细胞结构记忆特性的细胞增殖支架的生产方法

摘要

A method for producing a scaffold for cell growth having structure memory characteristics, comprising the steps of producing a fibrillar or cocoon-like decellularized tissue matrix material, and an acidified hydrogel decellularization A step of producing tissue matrix particles and mixing the produced microfibrous or cage-like decellularized tissue matrix material and acidified hydrogel-like decellularized tissue matrix particles in a ratio, Performing injection, freezing treatment, and radiation treatment, and finally producing a porous cell growth scaffold that can be stored at room temperature. The scaffold produced by the production method is a porous cell growth scaffold that does not require chemical cross-linking, has biological activity, has stable three-dimensional structure and structure memory characteristics, and has excellent biocompatibility and completeness. It is biodegradable, supports cell proliferation, tissue and organ growth in vivo and in vitro, and is suitable for soft tissue wound and defect repair. [Selection] Figure 5
机译:一种用于生产具有结构记忆特性的细胞生长支架的方法,其包括以下步骤:制备原纤维或茧状脱细胞的组织基质材料;以及酸化的水凝胶脱细胞的步骤。制备组织基质颗粒并混合所产生的微纤维或笼状细胞的步骤。如脱细胞组织基质材料和酸化的水凝胶状脱细胞组织基质颗粒按一定比例进行注射,冷冻处理和放射处理,最终制得可在室温下保存的多孔细胞生长支架。通过该生产方法生产的支架是不需要化学交联的多孔细胞生长支架,具有生物活性,具有稳定的三维结构和结构记忆特性,并且具有优异的生物相容性和完整性。它是可生物降解的,在体内和体外支持细胞增殖,组织和器官生长,并且适用于软组织伤口和缺损修复。 [选择]图5

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