Non-aggregating bioconjugates of amylin and amylin mimetic compounds, compositions containing them, and their production and use

摘要

The present disclosure relates to amylin non-aggregating bioconjugates, amylin mimetic compounds, and combinations comprising the same, wherein the bioconjugate comprises at least one acyl unit. Methods of manufacture and use are provided here. In some embodiments, the non-aggregating amylin bioconjugates of the present invention may cause a lack of spontaneous production of amylin and / or deposition of extracellular amyloid fibrils that contribute to dysfunction or failure of systemic organs such as the pancreas or brain. Alternatively, it can be used to treat diseases associated with accumulation.