ACTIVATION ASSAY FOR DIAGNOSIS OF HEPARIN-INDUCED THROMBOCYTOPENIA

摘要

To provide a functional, easily automatable assay for establishing a heparin-induced thrombocytopenia (HIT) which can arise during a heparin therapy.SOLUTION: An assay method for detecting the presence of anti-PF4/heparin complex antibodies in a body-fluid sample comprises quantitatively measuring the amount of PF4 (platelet factor 4) secreted by thrombocytes activated upon an antibody-bound PF4/heparin complex binding to a thrombocyte surface in vivo.SELECTED DRAWING: None