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Method for reducing the level of protein-impurity complexes and aggregates in protein formulations by treatment with positively charged organic additives
Method for reducing the level of protein-impurity complexes and aggregates in protein formulations by treatment with positively charged organic additives
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机译:通过用带正电的有机添加剂处理降低蛋白质制剂中蛋白质杂质复合物和聚集体水平的方法
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摘要
Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
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