The measuring method and measurement device used using the electromagnetic field array type sensor of enhancing

摘要

PROBLEM TO BE SOLVED: To provide an array type sensor for measuring a target molecule or a nanoparticle: not by selectively capturing the target molecule or the nanoparticle by using chemical bond through a linker molecule or an aptamer; but by physically detecting a Raman scattering signal or an emission signal in an individual hot spot when a molecule or a light-emitting nanoparticle enters into an enhanced electromagnetic field hot spot.SOLUTION: A two-dimensional array of electromagnetic field hot spots is configured by two-dimensionally and periodically arranging metal nano-structures having the same shape and the same electromagnetic field enhancing effect. A spectrum of each hot spot is measured while scanning a laser beam or a sample stage to detect a target molecule, and thereby to detect molecules in a solution or to obtain abundance ratio of a plurality of molecules.SELECTED DRAWING: Figure 3