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Rational drug design targeting resistant gram-negative bacterial infections against polymyxin antibiotics
Rational drug design targeting resistant gram-negative bacterial infections against polymyxin antibiotics
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机译:针对多粘菌素抗生素耐药的革兰氏阴性细菌感染的合理药物设计
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摘要
The present invention relates to the identification and composition of aminoarabinase glycosyltransferase (ArnT) inhibitors or antagonists, methods of treating or preventing drug-resistant gram-negative infections, or gram-negative bacterial infections resistant to polymyxin antibiotics. It relates to their use in inhibiting increase. In certain embodiments, the inhibitor or antagonist can be administered in combination with one or more antibacterial agents. [Selection] Figure 1A
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