Efficacy and Safety of Polymyxin B in the Treatment of Infections Caused by Multidrug- Resistant Gram-Negative Infections: A Retrospective Review

摘要

The objective of the study was to evaluate the safety and efficacy of polymyxin B in the treatment of multidrug-resistant (MDR) gram-negative infections.Over the study period, a total of 39 patients received polymyxin B either as mono or combination therapy. Acinetobacter baurnanii was isolated in 29 patients (76%) and Pseudomonas aeruginosa in 10 patients (26%). Polymyxin B used ranged from 125,000 to 750,000 units per day for a mean duration of 11 days. There were 4 cases of renal toxicity (2 were reversible). There were 16 deaths (41%).Polymyxin B proved to be a reasonably safe and effective treatment for MDR Acinetobacter and Pseudomonas infections.