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Method for refolding antibody, method for producing refolded antibody, refolded antibody, and use thereof
Method for refolding antibody, method for producing refolded antibody, refolded antibody, and use thereof
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机译:重折叠抗体的方法,重折叠抗体的生产方法,重折叠抗体及其用途
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摘要
The present invention provides a method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof. The present invention provides a method for refolding an antibody in a liquid phase, the method comprising the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. The present invention also provides a process for producing a refolded antibody.
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