Pretreatment drug for T cell infusion therapy for immune checkpoint inhibitor resistant tumor

摘要

PROBLEM TO BE SOLVED: To provide a technique related to treatment for immune checkpoint inhibitor resistant tumor. In a T cell infusion therapy for an immune checkpoint inhibitor resistant tumor, a pharmaceutical composition for administration before administration of an antigen-specific T cell, comprising CD8 positive cytotoxicity derived from the antigen It is achieved by a pharmaceutical composition comprising an antigen-loaded nanogel in which a long-chain peptide antigen or protein antigen comprising a sex T cell recognition epitope and a CD4 positive helper T cell recognition epitope is loaded on a hydrophobic polysaccharide nanogel. [Selection] Figure 3