PRETREATMENT DRUG FOR T CELL INFUSION THERAPY FOR IMMUNE-CHECKPOINT INHIBITOR-RESISTANT TUMOR

摘要

[Problems to be solved] To provide a technique relating to a therapy against an immune checkpoint inhibitor-resistant tumor. [Solution] The problem can be solved by a pharmaceutical composition which is intended to be administered prior to the administration of T cells specific to an antigen in a T cell infusion therapy against an immune checkpoint inhibitor-resistant tumor, the pharmaceutical composition that comprises; a long peptide antigen or a protein antigen which contains CD8-positive cytotoxic T cell recognizing epitope(s) and/or CD4-positive helper T cell recognizing epitope(s) derived from the antigen, a hydrophobized polysaccharide-based nanogel, an antigen-loaded nanogel which contains the hydrophobized polysaccharide-based nanogel in which the long peptide antigen or the protein antigen is loaded.