Non-human animals with degenerative symptoms due to protein aggregation

摘要

The present invention provides a model animal for establishing an effective treatment for a protein aggregation disease represented by Alzheimer's disease and the like. More specifically, the present invention provides the following. (A) a non-human animal exhibiting a degenerative symptom due to protein aggregation, wherein the degenerative symptom due to protein aggregation is induced by protein misfolding and the degenerative symptom is promoted; and (B) the following (1) and A method for producing a non-human animal exhibiting a degenerative symptom caused by protein aggregation, including (2): (1) Inducing protein misfolding in non-human animals to cause degenerative symptoms due to protein aggregation in non-human animals; and (2) Promoting treatment of degenerative symptoms due to protein aggregation in non-human animals. To do.