Non-human animal exhibiting degenerative symptoms caused by protein aggregation

摘要

The present invention provides a model animal for establishing an effective treatment for a protein cohesive disease represented by Alzheimer's disease or the like. More specifically, the present invention provides the following. (A) a non-human animal exhibiting a metamorphosis caused by protein aggregation, wherein the metamorphosis caused by protein aggregation is induced by the misfolding of the protein and the metamorphosis is promoted; And (B) a method for producing a non-human animal exhibiting denatured symptoms caused by protein aggregation, comprising the following steps (1) and (2): (1) inducing misfolding of proteins in non-human animals, Causing degenerative symptoms in nonhuman animals; And (2) carrying out the promoting treatment of metamorphic symptoms caused by protein aggregation in non-human animals.