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Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
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机译:达托霉素类似物和制备达托霉素或达托霉素类似物的方法
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摘要
A method for the synthesis of daptomycin or a daptomycin analog is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogs can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogs can include a different fatty acid in the side arm of the daptomycin analog.
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