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Disulfiram and metal salt staggered oral dosing regimen and staggered-release oral unit dosage forms
Disulfiram and metal salt staggered oral dosing regimen and staggered-release oral unit dosage forms
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机译:双硫仑和金属盐交错口服给药方案和交错释放口服单位剂型
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摘要
This application relates to methods and compositions for the administration of disulfiram (DSF) and heavy metals zinc and copper for the treatment and prevention of medical conditions, such as cancer. DSF and copper as well as DSF and zinc form active complexes that have been shown to be effective in the treatment of cancers. However, as described herein, DSF is incompatible with either copper or zinc for simultaneous oral administration. Included herein are improved methods and oral dosage forms comprising DSF and copper and DSF and zinc in fixed dose combinations that are configured to temporally stagger release of either DSF and copper or DSF and zinc after ingestion.
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