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Use of a long acting GLP-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease

机译:长效GLP-1 /胰高血糖素受体双重激动剂在治疗非酒精性脂肪肝中的用途

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease including a long-acting GLP-1/glucagon receptor dual agonist, and a method for preventing or treatment of non-alcoholic fatty liver disease including administering the composition. The composition of the present invention either has no side effect of weight gain or reduces the side effect of weight gain, which is a side-effect of conventional therapeutic agents for non-alcoholic fatty liver disease, and reduces the amount of administrations of a long-acting GLP-1/glucagon receptor dual agonist, thus greatly improving patient's convenience. In addition, the long-acting GLP-1/glucagon receptor dual agonist of the present invention improves in vivo sustainability and stability.
机译:本发明涉及用于预防或治疗非酒精性脂肪肝疾病的药物组合物,其包括长效GLP-1 /胰高血糖素受体双重激动剂,以及用于预防或治疗非酒精性脂肪肝疾病的方法,包括给药组成。本发明的组合物不具有体重增加的副作用或减轻体重增加的副作用,这是用于非酒精性脂肪肝疾病的常规治疗剂的副作用,并且减少了长期服用的量。作用的GLP-1 /胰高血糖素受体双重激动剂,从而大大提高了患者的便利性。另外,本发明的长效GLP-1 /胰高血糖素受体双重激动剂改善了体内的可持续性和稳定性。

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