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Efficient aqueous encapsulation and controlled release of bioactive agents
Efficient aqueous encapsulation and controlled release of bioactive agents
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机译:高效水囊包封和生物活性剂的控释
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摘要
A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
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