首页>
外国专利>
Prokaryotic 2-component signaling pathways for use as logic gates in mammalian cells
Prokaryotic 2-component signaling pathways for use as logic gates in mammalian cells
展开▼
机译:用作哺乳动物细胞逻辑门的原核2组分信号通路
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to mammalian cells comprising at least one prokaryotic two-component signaling (TCS) pathway comprised of an activator protein A, a response regulator (RR) protein B activated by said protein A, such activation leading to an activated RR protein B, and an output gene C operably linked to a promoter. Transcription from said promoter is activated by activated RR protein B, and the expression of output gene C defines at least a first state (0, no transcription) and a second state (1, detectable transcription). The invention further relates to logic gates designed from such cells, and methods for integrating a plurality of output signals based on the cells and logic gates of the invention.
展开▼