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Morphogenetically active amorphous calcium polyphosphate nanoparticles for therapeutic applications
Morphogenetically active amorphous calcium polyphosphate nanoparticles for therapeutic applications
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机译:形态发生活性的无定形聚磷酸钙纳米粒子,用于治疗应用
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摘要
This invention concerns a calcium polyphosphate material consisting of amorphous nanoparticles with a diameter of approximately between about 45 nm to about 0.25 μm that displays a considerable hardness (elastic modulus) of about 1.3 GPa. The inventive noncrystalline and biodegradable material that is produced under mild conditions, at room temperature, is morphogenetically active and preferably induces bone formation and the expression of the marker gene for osteoblast activity, alkaline phosphatase. In a preferred aspect, the invention concerns a method for producing amorphous retinol/calcium-polyphosphate nanospheres (retinol/aCa-polyP-NS) that show several unexpected properties and can be used in the treatment or prophylaxis of a variety of dermatological conditions, including photoaging.
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