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MULTI-ARRAY IMPEDIMETRIC BIOSENSORS FOR THE DETECTION OF CONCUSSION AND TRAUMATIC BRAIN INJURIES
MULTI-ARRAY IMPEDIMETRIC BIOSENSORS FOR THE DETECTION OF CONCUSSION AND TRAUMATIC BRAIN INJURIES
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机译:多阵列阻抗生物传感器用于检测创伤性和创伤性脑损伤
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摘要
The invention relates to ex-situ biosensors that impedimetrically detect one or more target biomarkers of interest in bodily fluid sample derived from a patient. The biosensors include a multi-array of conducting material, such as platinum wires, having immobilized thereon antibody and/or aptamer that is selected to specifically and selectively bind to the one or more target biomarkers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the antibody and/or aptamer binds to the target biomarker(s) of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in the electrochemical impedance is indicative of the presence of the target biomarker(s) of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic and health emergency settings.
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