Animal model of repetitive mild traumatic brain injury for human traumatic axonal injury and chronic traumatic encephalopathy

摘要

Chronic traumatic encephalopathy(CTE)is a chronic neurodegenerative disease featured with tauopathy.CTE is tightly related with repetitive mild traumatic brain injury(m TBI),which is interchangeably known as concussion(Mc Kee et al.,2009,2013).This disease is differentiated by neuropathological features from other neurological diseases that involve tau protein aggregation and tangle formation abnormalities like Alzhei-