VASCULAR NETWORK ORGANIZATION VIA HOUGH TRANSFORM (VaNgOGH): A RADIOMIC BIOMARKER FOR DIAGNOSIS AND TREATMENT RESPONSE

摘要

Embodiments access a radiological image of tissue having a tumoral volume and a peritumoral volume; define a vasculature associated with the tumoral volume; generate a Cartesian two-dimensional (2D) vessel network representation; compute a first set of localized Hough transforms based on the Cartesian 2D vessel network representation; generate a first aggregated set of peak orientations based on the first set of Hough transforms; generate a spherical 2D vessel network representation; compute a second set of localized Hough transforms based on the spherical 2D vessel network representation; generate a second aggregated set of peak orientations based on the second set of Hough transforms; generate a vascular network organization descriptor based on the aggregated peak orientations; compute a probability that the tissue is a member of a positive class based on the vascular network organization descriptor; classify the ROI based on the probability; and display the classification.