ORGAN HUMANIZED MOUSE

摘要

The present invention provides embryonic stem cells obtained from an embryo of a mouse engineered to replace all or some of domains in the mouse MHC class I molecule H2-D with domains from the human MHC class I molecule HLA-A by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a mouse which is created with the use of these embryonic stem cells.