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MULTIVALENT PNEUMOCOCCAL VACCINE COMPOSITIONS COMPRISING POLYSACCHARIDE-PROTEIN CONJUGATES

机译:包含多糖蛋白结合物的多价肺炎球菌疫苗组合物

摘要

The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
机译:本公开涉及多价肺炎球菌疫苗组合物,其包含荚膜肺炎球菌多糖血清型,每个血清型分别与载体蛋白缀合。当缀合时,荚膜肺炎球菌多糖血清型和载体蛋白的组合在本文中称为多糖-蛋白缀合物。肺炎球菌疫苗组合物可进一步包含以下一种或多种:药学上可接受的载体,药学上可接受的稀释剂,缓冲剂,防腐剂,稳定剂,佐剂和/或冻干赋形剂。还提供了制备和施用本文所述的肺炎球菌疫苗组合物的方法。

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