multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates

摘要

The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes individually conjugated to carrier proteins. when conjugated, the combination of capsular pneumococcal polysaccharide serotype and carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following: a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant and / or a lyophilization excipient. Methods for preparing and administering the pneumococcal vaccine compositions described in this report are also provided.