SELF-LEARNING LINEAR REGRESSION ON A DNA-COMPUTING PLATFORM

摘要

A method and associated systems for using machine-learning methods to perform linear regression on a DNA-computing platform. One or more processors generate and initialize beta coefficients of a system of linear equations. These initial values are encoded into nucleobase chains that are then padded to a standard length. The chains are allowed to bind with complementary template chains in a DNA-computing reaction, and the resulting DNA molecules are decoded to reveal the relative the relative likelihood of each chain to bind. The initial values of the beta coefficients are weighted proportionally to these likelihoods, and the process is repeated iteratively until the beta coefficients converge to optimal values.