METHOD FOR INCREASING BINDING AFFINITY OF IGG-LIKE ANTIBODY TO FCRN AND PROLONGING SERUM HALF-LIFE THEREOF

摘要

Provided a method for increasing binding affinity of an IgG-like antibody to FcRn and prolonging serum half-life thereof The method comprises mutating amino acids at positions 254, 308 and 434 in an FcRn-binding site of a heavy chain constant region of the IgG-like antibody.