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Modification of the Fc Region of a Human Anti-oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half-life in Cynomolgus Monkeys

机译：改变人抗脑炎米单克隆抗体的Fc区，对Fcrn受体的亲和力较高，在Cynomolgus猴中延伸半衰期

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Ivo P. Nnane; Chao Han; Qun Jiao; Susan H. Tam; Hugh M. Davis; Zhenhua Xu;
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1. Modification of the Fc Region of a Human Anti‐oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half‐life in Cynomolgus Monkeys [J] . Nnane Ivo P., Han Chao, Jiao Qun, Basic & clinical pharmacology & toxicology. . 2017,第1期

机译：修饰人抗癌素M单克隆抗体的Fc区，对FCRN受体的亲和力较高，延伸半衰期在Cynomolgus猴子中
2. Modification of the Fc Region of a Human Anti‐oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half‐life in Cynomolgus Monkeys [J] . Nnane Ivo P., Han Chao, Jiao Qun, Basic & clinical pharmacology & toxicology. . 2017,第Suppla1期

机译：修饰人抗癌素M单克隆抗体的Fc区，对FCRN受体的亲和力较高，延伸半衰期在Cynomolgus猴子中
3. FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys [J] . Datta-MannanA., ChowC.-K., DickinsonC., Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2012,第8期

机译：为改善食蟹猴的体外FcRn结合特性而设计的五种人IgG4抗体的FcRn亲和力-药代动力学关系
4. Production of Human Monoclonal Antibodies Against FC Epsilon Receptor I Alpha by Combining In Vitro Immunization with Phage Display [C] . Kosuke Tomimatsu, Shin-ei Matsumoto, Makiko Yamashita, Annual and International Meeting of the Japanese Association for Animal Cell Technology . 2010

机译：通过将体外免疫与噬菌体展示组合来生产对Fcε受体Iα的人单克隆抗体的生产
5. Investigation of the role of FcRn in the absorption, distribution, and elimination of monoclonal antibodies. [D] . Garg, Amit. 2007

机译：研究FcRn在吸收，分布和消除单克隆抗体中的作用。
6. Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models [O] . Delphine Valente, Christine Mauriac, Thorsten Schmidt, 2020

机译：新型FC工程单克隆和多特异性抗体的药代动力学在Cynomolgus猴和人源化FCRN转基因小鼠模型中
7. 1002 KPL-716, an anti-oncostatin M receptor β (OSMRβ) monoclonal antibody, reduces IL-31-induced scratching behavior in cynomolgus monkeys: Establishment and optimization of a PK/PD model [O] . R. Gandhi, K. Crowder, K. Barrow, 2019

机译：1002 kP1-716，抗脑刺素M受体β（OSMRβ）单克隆抗体，降低了在Cynomolgus猴中的IL-31诱导的刮伤行为：建立和优化PK / PD模型

Modification of the Fc Region of a Human Anti-oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half-life in Cynomolgus Monkeys

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