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METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER

机译:预测微卫星不稳定癌症患者生存时间的方法

摘要

The present invention relates to methods for predicting the survival time of patients suffering from a micro satellite unstable cancer. In particular, the present invention relates to a method for predicting the survival time of a patient suffering from a micro satellite unstable cancer comprising i) determining the expression level of at least one gene encoding for an immune checkpoint protein in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is higher than the predetermined reference value.
机译:本发明涉及用于预测患有微卫星不稳定癌症的患者的存活时间的方法。特别地,本发明涉及一种用于预测患有微卫星不稳定癌症的患者的生存时间的方法,该方法包括:i)确定在从获得的肿瘤组织样品中编码免疫检查点蛋白的至少一个基因的表达水平。 ii)将步骤i)中确定的表达水平与预定参考值进行比较;以及iii)当步骤i)中确定的水平低于预定参考值时得出结论,患者的生存时间较长或得出结论当在步骤i)中确定的水平高于预定参考值时,患者将具有较短的生存时间。

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