首页>
外国专利>
SCREENING METHOD OF ANTICANCER AGENT FOCUSED ON FUNCTION OF HP1 AND EVALUATION SYSTEM
SCREENING METHOD OF ANTICANCER AGENT FOCUSED ON FUNCTION OF HP1 AND EVALUATION SYSTEM
展开▼
机译:HP1功能评估剂的筛选方法及评估系统
展开▼
页面导航
摘要
著录项
相似文献
摘要
The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1α, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.
展开▼