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D-Lactate Dehydrogenase, Engineered Strain Containing D-Lactate Dehydrogenase and Construction Method and Use of Engineered Strain
D-Lactate Dehydrogenase, Engineered Strain Containing D-Lactate Dehydrogenase and Construction Method and Use of Engineered Strain
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机译:D-乳酸脱氢酶,含有D-乳酸脱氢酶的工程菌株及其工程方法和用途
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摘要
Provided herein is D-lactate dehydrogenase, an engineered strain containing the D-lactate dehydrogenase, and a construction method and use of the engineered strain. The D-lactate dehydrogenase has unique properties and is from Thermodesulfatator indicus, and the D-lactate dehydrogenase has good thermophily and heat stability. By using the D-lactate dehydrogenase and said gene engineering reconstruction method, a fermentation product of the reconstructed Bacillus licheniformis can be redirected to optically-pure D-lactic acid with a high yield from naturally produced 2,3-butanediol, and the optical purity of the produced D-lactic acid reaches 99.9%; and raw materials for fermentation are low-cost, and a fermentation state is between an anaerobic fermentation state and a microaerobic fermentation state. By using the method for producing D-lactic acid through fermentation at high temperature, the production cost can be reduced, the production efficiency can be improved and there is a wide industrial application prospect for the method.
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