2. Pyridine-3-IL-Ac acid derivatives as replication inhibitors of human immunodeficiency virus

摘要

Propagation formula compound (1),Including pharmaceutically acceptable salts, pharmaceutical compounds including compounds, procedures for the preparation of compounds and their use in the suppression of HIV syndrome and in the treatment of people living with HIV / AIDS. 1. Claim 1: a formula compound (1),O including: R1 is hydrogen, halogen, cyanogen and alkyl c83218331; 8320;a. Halogenated tar c83218d318321; 8320;-C₁₋₁₀-OH alkyl, HO-C₁₋₁₀-O- alkyl,Ar1,-N (R) (R)-C (O) N (R⁷) (R⁸) or (R⁹) (R¹⁰) N-C₁₋₁₀ alkyl;2. The condition is that R 1 and r830808 are non asphalt, R2 is benzodioxillo, naftelenio, fenilo, pirazi Nile, pirizilo, pirimidinilo, quinoline, isoquioli Nile, tetrazinilo or trizinilo, and can be replaced by 1-4 alternatives selected from cyanogen, carbamoyo, carbocilo, halo, hidroxi, c83318321 tar;a. Halogenated tar c83218d318321; 8320;-N (R) (R)C₁₋₁₀-O- alkyl,AR830808,Ar⁴-C₁₋₁₀-O- alkyl,(R⁵) (Ar⁴-C₁₋₁₀ alkyl) N-,a. Ar83088-o-lessor c83221131; ar832008-o (ar830808) (r8309099) n-lessor c83318321; - iv8320;R³ is C₁₋₁₀ alkyl;R⁴ is hydrogen, cyano, halo, haloalkyl C₁₋₁₀,C₁₋₁₀ alkyl,C₁₋₁₀-O- alkyl,alquenilo CNH.8322;e. Hidroxi acquilo c83318321; 8320oh, carbamoyo, azetidini, pirrolidini, piperidinilo, morfolino or piperaznilo; provided that R1 and r830808 are not two kinds of aspha r8309es hydrogen or c83318321; 8320;R8310s is hydrogen, c832131 hydrocarbon; 8320;C₁₋₁₀-O-C₁₋₁₀- alkyl,1. C-832188331-8321; 8320a-o-c (o) -,C₃₋₉ cycloalkyl,(Cicloalquilo C) alquilo C -1 - (rent c83218c83318321); 8320piperidinilo -,Keywords tetrahydropiranil hydrocarbon c83318321; 8320 -;morpholin-C₁₋₁₀- alkyl,(Alquilo C) N-alquilo C -piperidinyl-C₁₋₁₀- alkyl,1 - (c) piperidinil asphalt c832188321; 8320;1- (alquilo C) piperazinil-alquilo C -Arz - lessor c832183.318321; 8320a;Harp.1- (alquilsulfonil C) piperidinilo- o 1- (alquilcarbonil C) piperidinil-R8311811 is hydrogen or c832131; 83218320;R831222 is hydrogen, c8321 aspha 8320;C₃₋₉ cycloalkyl,(Alquilo C) cicloalquilo C --So83223 (rent c832183 31); or - so83222 (rent c8332323);R8313 is hydrogen or c8332131; 8321; 8320;R¹⁰ is hydrogen, C₁₋₁₀ alkyl,(tetrahydropyranyl) C₁₋₁₀ alkyl or C₁₋₁₀-O-C- (O) alkyl;(R⁷) (R⁸) N taken together form an azetidinyl, pyrrolidinyl, piperidinyl, 1,1-dioxidothiomorpholinyl or a morpholinyl ring group; (R⁹) (R¹⁰) N taken together form an azetidinyl, azocanyl, pyrrolidinyl. piperidinyl or an azaspirononanyl ring and are optionally substituted with 1-3 C₁₋₁₀ alkyl substituents;AR1 es imidazollo, pirazolilo, pirid Nile, pirimidinilo, pirrolilo or dihydrocyclopentapirazolilo can be replaced by 1-3 alternatives selected from ammonia, hydrocarbon c833218331a and / or c833238331a;Ar² is imidazolyl, pyrazolyl or pyridinyl and is optionally substituted with 1-3 substituents selected from C₁₋₁₀ alkyl and halo substituents; Ar³ is phenyl, pyridinyl, pyrazolyl, pyridazinyl or pyrimidinyl and is optionally substituted with 1-3 substituents selected from C₁₋₆ alkyl,a. Halo, caboxi and Ciano; and AR 8308088 are phenyl, benzofuran or pyridan, which can be replaced by 1-3 alternatives selected from cyanogen, halo, c8332131 tar and c833183221 tar;Each of the terms "halogenated tar" includes all halogenated isomers from one halogenated to perhalo.