1', 2'-dihydrofluoroalkyl cyclohexane-1, 3'-indanediol or 1', 2'-dihydrohelix cyclohexane-1, 3'-pyridine as inhibitors of hexamethylphosphatase quinase

摘要

A heterocyclic compound with IP6K inhibitory effect is expected to be an effective agent for the prevention or treatment of heart failure and other diseases.Diabetes.And similar. This compound has IP6K inhibitory effect and is expected to be an effective agent for the prevention or treatment of heart failure and other diseases.Diabetes mellitus, etc. Proposition 1: Compounds represented by formulas (1)The sign is that Ring A is an optional fragrant ring.X is CH or N;Or one of the salts Claim 2: Compounds meeting Claim 1,A. Odorous cycles of aromatic compounds C83268331832183248324 or 5 to 14 members with ring A.Each of these substitutes is selectively replaced by one to three substitutes selected from (a) a halogen atom.(b) A cyanide group,(c) An anthrax team,(d) A group of C832183318326 alternative halides;(e) One Alcoxi C832183318326;(f) One cycloquilo C83231 and 8321; 8320y (g) and one Aralquil C832783331 and 8321; 83832626-ox;Or one of the salts