fusion protein constructs that have thrombolytic and anticoagulant properties

摘要

fusion protein constructs that have thrombolytic and anticoagulant properties. The present invention describes novel hybrid proteins that have both plasminogen and antithrombotic activating properties, including clot-specific action, which make them highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage leading to blood vessels. myocardial infarction, strokes, etc. Also described are novel proteins, and methods of obtaining them, which help to dissolve blood clots by plasminogen activation in a plasmin or thrombin-dependent manner and also inhibit both thrombin activity and generation via the intrinsic pathway. blood clotting.